New publication in Immunity
Our latest research has just been published in the prestigious journal Immunity.
How monocyte fate is directed towards monocyte-derived macrophages (mo-Mac) or monocyte-derived DC (mo-DC) and which transcription factors control these differentiation pathways has remained unclear. Using a novel in vitro culture model that we have developped, yielding human mo-DC and mo-Mac that closely resemble those found in vivo in inflammatory fluids, we show that IRF4 and MafB are critical regulators of monocyte differentiation into mo-DC and mo-Mac, respectively. In addition, we found that activation of the aryl hydrocarbon receptor (AhR) promotes mo-DC differentiation, while impairing differentiation into mo-Mac. Our results establish mo-DC and mo-Mac as two bona fide cell lineages, controlled by distinct specifying transcription factors and show that AhR acts as a molecular switch for monocyte fate specification in response to micro-environmental factors.
You can read the article here: http://www.cell.com/immunity/fulltext/S1074-7613(17)30374-6.
Aryl Hydrocarbon Receptor controls monocyte differentiation into dendritic cells versus macrophages
How monocyte fate is directed towards monocyte-derived macrophages (mo-Mac) or monocyte-derived DC (mo-DC) and which transcription factors control these differentiation pathways has remained unclear. Using a novel in vitro culture model that we have developped, yielding human mo-DC and mo-Mac that closely resemble those found in vivo in inflammatory fluids, we show that IRF4 and MafB are critical regulators of monocyte differentiation into mo-DC and mo-Mac, respectively. In addition, we found that activation of the aryl hydrocarbon receptor (AhR) promotes mo-DC differentiation, while impairing differentiation into mo-Mac. Our results establish mo-DC and mo-Mac as two bona fide cell lineages, controlled by distinct specifying transcription factors and show that AhR acts as a molecular switch for monocyte fate specification in response to micro-environmental factors.
You can read the article here: http://www.cell.com/immunity/fulltext/S1074-7613(17)30374-6.
Published on : 19/09/2017